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With improved oral diagnosis and treatment in Guangzhou, residents enhanced their awareness of dental health care, and their demands for dental and medical services were increasing greatly. While service demands showed more diverse, service quality became more critical. Patient loyalty, defined as a behavior intention with intense satisfaction, would a crucial element to business success for healthcare service providers based on the influencing factors of hospital service level, service attitude, medical technology, medical care service, hospital culture, and brand image to patient satisfaction. The study objectives were to explore the attitude of Guangzhou dental patients in service satisfaction based on the demographic factors of gender and education; analyze the influencing factors of hospital service level, service attitude, medical technology, medical care service, hospital culture, and brand image in brand building strategies of dental hospital for patients' service satisfaction, and; suggest the improvement of brand building strategies of dental hospital for patient service satisfaction in Guangzhou. 420 questionnaires of Guangzhou residents were collected through the online WeChat platform by random sampling in June 2022. The results showed that Hospital service level, service attitude, medical technology, medical care service, hospital culture, and brand image significantly impact Guangzhou dental patients. As a result, this study would offer suggestions to dental hospitals in Guangzhou in enhancing their brand building strategies for local dental patients.