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This study examined the factors that influence human resource management practices in organizational performance. This study used a descriptive approach to collect, analyze, interpret, and present information. Descriptive research design helped determine the strength of the relationship between human resource management practice factors affecting organizational performance in the Guizhou private university environment. This study aimed to study the influence between human resource management intensity and organizational performance in private universities, explore the moderating role of employee innovation performance on organizational performance in Guizhou private universities, and suggest the proper management practice for developing school employees' job satisfaction. Three hundred and ninety-four completed questionnaires of Guizhou school employees were collected through the online WeChat platform by random sampling in June of 2022. The results showed that external satisfaction of transactional and transformational leadership significantly impacted school employees' performance, and the internal satisfaction of patchwork elements and resources significantly impacted school employees' innovative behavior in Guizhou private universities for the school policymakers in considering the development of organizational behaviors in the school environment.